South Asian Research Journal of Natural Products <p style="text-align: justify;"><strong>South Asian Research Journal of Natural&nbsp;Products</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/SARJNP/general-guideline-for-authors">Click here for Types of paper</a>) covering all aspects of research&nbsp;of naturally occurring compounds or the biology of living systems from which they are obtained.</p> South Asian Research Journal of Natural Products en-US South Asian Research Journal of Natural Products Evaluation of Analgesic and Antipyretic Activity of Ethanolic Leaf Extract of Catharanthus roseus (Nayantara) in Experimental Animals <p><em>Catharanthus roseus</em> has traditionally been used for relieving pain and inflammation. Few studies have been done to scientifically evaluate its analgesic and anti-pyretic activity. Hence our aim was to evaluate the analgesic and anti-pyretic activity of leaves of <em>Catharanthus roseus</em> in experimental animals.</p> <p><strong>Objective: </strong>To evaluate the analgesic and antipyretic activity of <em>Catharanthus roseus</em> leaf extract in animal models.</p> <p><strong>Study Design:</strong> Experimental study of analgesic and antipyretic activity in animal models.</p> <p><strong>Place of Study:</strong> Department of Pharmacology, Assam Medical College &amp; Hospital, Dibrugarh, Assam, India.</p> <p><strong>Methodology:</strong> We prepared ethanolic extract of the powdered leaves of <em>Catharanthus roseus</em> (CREE). 30 healthy albino mice (20-35 g) of either sex were assigned to five groups of six animals each and administered the vehicle or drug as follows - Group I or normal control (gum acacia 10 ml/kg), Group II (CREE 100 mg/kg), Group III (CREE 250 mg/kg), Group IV (CREE 500 MG/KG) and Group V (Aspirin 100mg/kg). We assessed analgesic activity by writhing following 0.6 % glacial acetic acid i.p. injection and recording reaction time in Eddy’s Hot Plate method. Thereafter, five groups of six Wistar albino rats each were treated with the above doses in Groups I -&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IV and Paracetamol 50 mg/kg in Group V following s.c. injection of 20% aqueous suspension of dried yeast at 20 ml/kg to induce fever. Rectal temperature (Celsius) for anti-pyretic activity was recorded. Quantitative variables were expressed as Mean ± SD and one way ANOVA followed by Tukey’s multiple comparison test were used for statistical analysis with <em>P</em>&lt;0.05 at 95% confidence level.</p> <p><strong>Results:</strong> Writhing response was significantly decreased (<em>P</em>&lt;0.05) in test groups compared to control with dose dependent effect. Reaction time of mice to thermal pain stimulus in test groups was significantly increased (<em>P</em>&lt;0.05) over time in hot plate method. Significant temperature reduction was not observed in test groups compared to control. (<em>P</em>&gt;0.05).</p> <p><strong>Conclusion:</strong> Ethanolic extract of leaves of <em>Catharanthus roseus</em> possesses significant analgesic but not anti-pyretic activity.</p> Kingshuk Lahon Dwipen Khanikar Anita Rajowar Swarnamoni Das ##submission.copyrightStatement## 2022-01-17 2022-01-17 1 12 Tert-Butylhydroquinone's Effect on Oxidative Stress Indices in High Fructose Challenged Rats' Skeletal Muscle <p>Antioxidant and oxidative stress effects of prooxidants are generally dose-dependent, depending on the prooxidant species and cell type. However, the cellular response to oxidant challenge is a complicated interplay of events involving cellular expression of phase II detoxification enzymes and cellular metal metabolism. The study aimed to determine tert-butylhydroquinone's effect on oxidative stress indices in high fructose-challenged rats' skeletal muscles. A total of thirty (30) experimental rats were used in this study and weighed between 150 to 183 g. The rats were grouped into four (4) groups. Group, I (control) received distilled water and standard rat pellets. Group II (disease or fructose drinking group) received 21% of fructose drinking water (w/v) and standard rat pellets. Group III (Positive control or metformin group) received 21% of fructose drinking water and oral administration of metformin (300 mg/kg body weight daily), group IV (Test group): received 21% of fructose drinking water and 1% tert-butylhydroquinone feed. The rats were fed for 49 days (7 weeks). Preparation of skeletal muscle homogenates and assay of biochemical parameters were carried out. From our results, there was a non-significant elevation/decrease for all enzymes; thus, catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione-S-transferase (GST) activity in the skeletal muscles of rats at (P&gt;0.05) when compared to the control. MDA and GST activity expressed upregulation, while SOD and CAT expressed downregulation. TBHQ can ameliorate insulin resistance in the skeletal muscle of high fructose challenged rats, providing evidence for TBHQ's clinical use to treat T2DM.</p> Cynthia Onyinye Ugwu Onyinyechi Justina Omaba George Chigozie Njoku Njideka Victoria Stephen ##submission.copyrightStatement## 2022-06-16 2022-06-16 13 19 Analysis of Water Based Carbon Nanotubes on an Inclined Porous Sheet with Variable Magnetic Field <p>In this research, I investigated an unsteady carbon nanotubes in a 2D mixed convection flow made of water on a porous in- clined expansible surface with angle in terms of the horizontal axis. When the magnetic field changes, the surface stretches linearly with velocity u.The Parametric Continuation Method is used to examine unknown physical quantities (PMC). The PDEs and boundary conditions are integrated using similarity transformations to generate a set of coupled ODEs.Physical quantities such as flow behavior, thermal characteristics, thermal variation, skin friction and Nusselt Number are examined using graphical and tabulated results for physical purposes.</p> Rabia Awan Rehan Ali Shah M. Sohail Khan ##submission.copyrightStatement## 2022-06-27 2022-06-27 20 28 Magnetic Field Dependent Thermosolutal Convection Flow between Two Squeezing Plates <p>The effect of magnetic field dependent thermosolutal convection and MFD viscosity of the fluid dynamic are studied between two squeezing plates. The unsteady constitutive expression of mass conservation modified naiver-stocks, Maxwell and MFD thermosolutal convection are coupled as a system of ordinary differential equations. The corresponding solution for momentum as well as solution for the magnetic field equations are determined by the PCM method. The validity and accuracy of PCM results is proved by the comparison of the PCM solution with numerical solver package BVP4c.It has been shown the magnetic Reynold number caused to decrease the flow, magnetic field distribution and temperature of the fluid. Also x-component and y- component of magnetic field have opposite behavior with increase in MFD viscosity.</p> Muhammad Basit Ali Khan Rehan Ali Shah Sohail Khan ##submission.copyrightStatement## 2022-06-30 2022-06-30 29 42