South Asian Research Journal of Natural Products 2020-09-10T08:24:38+00:00 South Asian Research Journal of Natural Products Open Journal Systems <p style="text-align: justify;"><strong>South Asian Research Journal of Natural&nbsp;Products</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/SARJNP/general-guideline-for-authors">Click here for Types of paper</a>) covering all aspects of research&nbsp;of naturally occurring compounds or the biology of living systems from which they are obtained.</p> Phytochemical Analysis of Portulaca pilosa & Portulaca quadrifida Linn through FTIR 2020-08-08T10:39:04+00:00 Muhammad Aslam Tahir Muhammad. S. A. Abbasi <p>Current research work comprises Fourier Transform Infrared (FTIR) study of two members of Portulaca Family namely, <em>Portulaca pilosa &amp; Portulaca quadrifida Linn</em>. <em>Portulaca pilosa</em> is well known ornamental plant whereas <em>Portulaca quadrifida Linn</em>. is a weed. Both are known for their herbal importance and were grown in March last year in self-built herbal garden. In June last year, twigs of both herbs were plucked and kept under shade for drying. After one month, dry twigs were ground to fine powder and then analyzed using FTIR technique. Functional groups of phytochemicals were identified through FTIR spectral lines. Appropriate correlations of absorption peaks to medicinal compounds have been discussed. As a result, both herbs are found to be rich source of bioactive compounds like alkaloids, flavonoids, fatty acids, tannins, triterpenoids, amino acids and saponins. In conclusion of current study, importance of herbal plants for development of medicines is also highlighted.&nbsp;</p> 2020-08-08T00:00:00+00:00 ##submission.copyrightStatement## In vitro Antiplasmodial and Cytotoxicity Evaluation of Ethanol Leaf Extract of Erythrina senegalensis DC 2020-09-03T12:33:28+00:00 David Adeniran Adedapo Al-Mubarak Oumar Adoum Sulaiman Ayodeji Apampa <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: inter-ideograph; line-height: normal;"><span style="font-size: 10.0pt; mso-bidi-font-size: 11.0pt; font-family: 'Arial','sans-serif'; mso-fareast-font-family: Calibri;">This study evaluates <em style="mso-bidi-font-style: normal;">in vitro</em> antiplasmodial and cytotoxicity activity of an ornamental plant commonly employed in Northern part of Nigeria for curing malaria infection. Fresh mature leaves of <em style="mso-bidi-font-style: normal;">Erythrina senegalensis</em> were collected, air dried, ground, percolated in ethanol for two weeks and evaporated to dryness at room temperature. The dried ethanol crude extract was fractionated with pet-ether, chloroform, ethyl acetate and methanol in order of increasing polarity. These were screened for phytochemicals, <em style="mso-bidi-font-style: normal;">in vitro </em>antiplasmodial and cytotoxicity test using standard procedures. The results of the phytoconstituents revealed the presence of alkaloids, tannins, flavonoids and terpenoids which could be responsible for the medicinal properties of the extract. Ethanol crude extract, pet-ether and ethyl acetate fractions were discovered to be non-cytotoxic exhibiting LC<sub>50</sub> &gt; 1000 µg/ml respectively. Only methanol fraction showed slight toxicity with LC<sub>50</sub> value of 630 µg/ml. The highest activity of the extract and its fractions against <em style="mso-bidi-font-style: normal;">Artemia salina</em> larvae was recorded at 1000 µg/ml dose whereas lowest larvicidal activities and lethalities occurred at 10 µg/ml dose. The ethanol extract and its fractions were significantly active against <em style="mso-bidi-font-style: normal;">Plasmodium falciparum</em> strain (K1) with percentage elimination of the parasites were in the range of 77% - 83% at 5000 µg/ml. Ethyl acetate (71%) and methanol fraction (71%) were found to be the most active fractions at the lowest concentration of 625 µg/ml. This finding justifies the usage of the plant in traditional medicine by traditional healers and local populace against malaria disease. The observed value for cytotoxicity assay of LC<sub>50</sub>&gt;1000 µg/ml recorded for the ethanolic extract suggested that oral intake of the extract could be deemed safe and would not be lethal at low/moderate dose as lethality is directly proportional to dosage and oral consumption of the extract as over dosage could lead to lethality and subsequently, mortality over a long period of time due to bioaccumulation. The isolation of antiplasmodial compounds from the leaves of the plant is necessary as it could be a potential candidate for novel antimalarial drugs. Continuous utilization of the leaves as antimalarial and the wide range of its safety at low and moderate dosages further supports its use among the less privileged and vulnerable people in malaria endemic areas in lieu of existing expensive modern antimalarial drugs.</span></p> 2020-09-03T00:00:00+00:00 ##submission.copyrightStatement## Antioxidant Activity of Some Whole Fruit Cultivars of Raw and Processed (Boiled) Egg Plant (Solanum melongena) 2020-09-10T08:24:38+00:00 Enumah Ogoamaka Ellis Odia Amraibure <p>Eggplant (<em>Solanum melongena) </em>is one of the most common vegetables consumed all around the world. It is a very rich source of polyphenol compounds endowed with antioxidant activity. The current study evaluated the antioxidant potential of seven different varieties of eggplant carried out both in raw and processed form in terms of total phenolic content, total flavonoid content and DPPH radical scavenging assay. The phenolic and flavonoid content were quantified by aluminum chloride and Folin-Ciocalteu methods, respectively. Processed extract from yellow eggplant showed more antioxidant activity (52.35 ± 0.75%), while raw extract from purple stripe eggplant showed more antioxidant activity than the other samples (83.00 ± 0.20%). It was also observed that values for all samples carried out&nbsp; for total phenolic and total flavonoid content&nbsp; both raw and processed extract was low which ranges from (7.65 ± 0.02 µg/g to 7.89 ± 0.04 µg/g) for raw extract and (7.60 ± 0.08 µg/g to 7.82 ± 0.24 µg/g) for processed extract in total phenolics and ( 62.09 ± 0.08 µg/g to 62.43 ± 0.05 µg/g) for raw extract and (62.43 ± 0.05µg/g to 62.56 ± 0.05 µg/g) for processed extract in total flavonoid, compared to values for DPPH, which ranges from (25.07 ± 0.47% to 83.00 ± 0.20%) for raw extract and (36.60 ± 0.19% to 57.03 ± 0.50%) for processed extract.</p> 2020-09-10T00:00:00+00:00 ##submission.copyrightStatement##