Preparation and Characterization of Some Oxazolidine-5-one Derivatives and Evaluation of their Biological Activity
Mohammed Jwher Saleh
Salah al-Din Education Directorate/Ministry of Education, Iraq.
Jamil Nadhem Saleh *
Salah al-Din Education Directorate/Ministry of Education, Iraq.
Khalid Al-Badrany
Department of Chemistry, College of Education for Pure Science, Tikrit University, Iraq.
Mohammeed. H. Yaseen
Nineveh Education Directorate /Ministry of Education, Iraq.
Marwan Hasan Ali
Nineveh Education Directorate /Ministry of Education, Iraq.
Abdul Wahed Abdul Sattar Talluh
Tikrit University, College of Basic Education, Shirqat, Tikrit, Iraq.
*Author to whom correspondence should be addressed.
Abstract
The research included the preparation of new compounds of oxazolidine-5-one from the reaction of prepared Schiff bases with chloroacetic acid in the presence of dioxane as a solvent. The preparation used the sublimation method, and the reaction was monitored and described by determining the melting point, yield, and color. The completeness of the reaction was confirmed using thin layer chromatography (T.L.C.), infrared spectroscopy (FT-IR), proton and carbon nuclear magnetic resonance (1H&13C-NMR), and quantitative elemental analysis (C.H.N.). The biological sensitivity of the prepared compounds was evaluated by examining their effect on the growth of two antibiotic-resistant bacterial isolates: Gram-negative (K. pneumoniae) and Gram-positive (Staph. epidermidis). The antibiotic ampicillin was used as a control sample; Compound J1 showed the highest activity against K. pneumonia, and compound J2 showed the highest activity against Staph. Epidermidis.
Keywords: Heterocyclic, oxazolidine-5-one, biological activity, characterization