An Assessment of Analgesic and Anti-inflammatory Activity of Manilkara zapota on Rat Model

Souvik Kumar Mandal

Department of Pharmacy, Gono Bishwabidyalay, Mirzanagor, Savar, Dhaka, Bangladesh.

Masruk Alam

Department of Pharmacy, Southeast University, Dhaka, Bangladesh.

Misuk Chandra Ray

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Eitika Roy

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Khadija Binte -A-Khaleque

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Tasnimur Rahman Khan

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Md. Mustafiz Chowdhury

Department of Pharmacy, University of Chittagong, Bangladesh.

Kazi Sakib

Department of Pharmacy, Southeast University, Dhaka, Bangladesh.

Isratul Jannat Mim

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Rafat Tahsin *

Department of Pharmacy, Gono Bishwabidyalay, Mirzanagor, Savar, Dhaka, Bangladesh.

*Author to whom correspondence should be addressed.


Abstract

Background: The word "herbal medicine" refers to using medicinal plants to prevent or treat sickness. This definition encompasses a broad range of practices, from the widespread usage of traditional medicines in every culture to the standardized and titrated extracts of herbs.

Aims: In this study, an extract of Manilkara zapota was administered to rats to investigate this plant's analgesic and anti-inflammatory properties.

Methods: The carrageenan-induced acute inflammation technique was used to test the anti-inflammatory activity, and the acetic acid writhing and Tail-flick method was used to evaluate the analgesic efficacy.

Results: Regarding the anti-inflammatory action, the 1,000 mg/kg dosage extract was the only one that exhibited a highly significant (p < 0.05) result. In contrast, the other doses didn't show any statistically significant difference. None of the groups showed statistically significant results using the acetic acid writhing technique in this test. The Tail-flick technique showed that a 1,000 mg/kg dose was statistically significant (p < 0.05) at both the 3 and 4 h time periods. The results took just 4 hours after the 750 mg/kg dosage to reach statistical significance (p < 0.05).

Conclusion: According to these findings, M. zapota exhibits both analgesic and anti-inflammatory efficacy when tested on rat models.

Keywords: Manilkara zapota, analgesic, anti-inflammatory, aspirin, herbal medicine, phytotherapy


How to Cite

Mandal , S. K., Alam , M., Ray , M. C., Roy , E., Binte -A-Khaleque , K., Khan , T. R., Chowdhury , M. M., Sakib , K., Mim , I. J., & Tahsin , R. (2023). An Assessment of Analgesic and Anti-inflammatory Activity of Manilkara zapota on Rat Model. South Asian Research Journal of Natural Products, 6(3), 177–184. Retrieved from https://journalsarjnp.com/index.php/SARJNP/article/view/123

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