An Assessment of Analgesic and Anti-inflammatory Activity of Manilkara zapota on Rat Model
Published: 2023-09-04
Page: 177-184
Issue: 2023 - Volume 6 [Issue 3]
Souvik Kumar Mandal
Department of Pharmacy, Gono Bishwabidyalay, Mirzanagor, Savar, Dhaka, Bangladesh.
Masruk Alam
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Misuk Chandra Ray
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Eitika Roy
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Khadija Binte -A-Khaleque
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Tasnimur Rahman Khan
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Mustafiz Chowdhury
Department of Pharmacy, University of Chittagong, Bangladesh.
Kazi Sakib
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Isratul Jannat Mim
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Rafat Tahsin *
Department of Pharmacy, Gono Bishwabidyalay, Mirzanagor, Savar, Dhaka, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Background: The word "herbal medicine" refers to using medicinal plants to prevent or treat sickness. This definition encompasses a broad range of practices, from the widespread usage of traditional medicines in every culture to the standardized and titrated extracts of herbs.
Aims: In this study, an extract of Manilkara zapota was administered to rats to investigate this plant's analgesic and anti-inflammatory properties.
Methods: The carrageenan-induced acute inflammation technique was used to test the anti-inflammatory activity, and the acetic acid writhing and Tail-flick method was used to evaluate the analgesic efficacy.
Results: Regarding the anti-inflammatory action, the 1,000 mg/kg dosage extract was the only one that exhibited a highly significant (p < 0.05) result. In contrast, the other doses didn't show any statistically significant difference. None of the groups showed statistically significant results using the acetic acid writhing technique in this test. The Tail-flick technique showed that a 1,000 mg/kg dose was statistically significant (p < 0.05) at both the 3 and 4 h time periods. The results took just 4 hours after the 750 mg/kg dosage to reach statistical significance (p < 0.05).
Conclusion: According to these findings, M. zapota exhibits both analgesic and anti-inflammatory efficacy when tested on rat models.
Keywords: Manilkara zapota, analgesic, anti-inflammatory, aspirin, herbal medicine, phytotherapy